双相障碍昼夜节律异常与时间治疗

双相障碍是一种常见的、致残率高的精神疾病，以早年发病、频繁发作、高自杀风险和慢性结局为显著特点，与严重的社会功能损害相关。双相障碍的发病机制仍不明确，目前研究主要集中在昼夜节律异常，包括节律基因突变、具有多态性、激酶表达异常以及神经递质分泌、转运节律异常等。已经发现在双相障碍任何时期，无论是前驱期、发作期或者缓解期患者...

Circadian rhythm abnormality and time therapy of bipolar disorder

Bipolar disorder is a common,highly disabling psychiatric disorder characterized by early onset,frequent episodes,high suicide risk,and chronic outcomes,and is associated with severe social dysfunction.The pathogenesis of bipolar disorder is still unclear,and current studies mainly focus on circadian rhythm abnormalities,including rhythm gene mutation,polymorphism,abnormal kinase expression,and rhythm abnormalities in neurotransmitter secretion and transport.It has been found that at any stage of bipolar disorder,whether prodrome,episode,or remission,patients exhibit circadian rhythm disruptions,including disrupted sleep-wake cycles,hormonal phase abnormalities,and irregular social rhythms.Based on this mechanism,the time therapy,such as light therapy,dark therapy,sleep deprivation and behavioral intervention,can rapidly improve the circadian rhythm of patients with bipolar disorder,achieve the goal of rapid relief of symptoms,with fewer side effects,low risk of switching to manic.In this paper,circadian rhythm mechanism,clinical manifestations and chronotherapy of bipolar disorder are reviewed to provide a basis for clinical diagnosis and treatment.