| Affiliation: | 1. Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UKThese authors contributed equally to this paper as joint first authors.;2. Nottingham Biomedical Research Centre, National Institute for Health Research (NIHR), Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK;3. London North West Healthcare NHS Trust, St Mark's Hospital, Middlesex, UK;4. Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK |
