艾司西酞普兰治疗2型糖尿病伴抑郁患者的对照研究

目的评价新型抗抑郁药艾司西酞普兰对T2DM患者抑郁症状控制的疗效及安全性。方法将符合抑郁标准的干预研究对象71例随机分为试验组35例和对照组36例,在治疗前及治疗后2、4、8周末分别对试验组和对照组进行汉密顿抑郁量表重复测评,并在8周末同时对两组行FBG、PBG2h复查及DSQL重复测评。结果HAMD量表测评结果及HAMD减分率组间比较均有统计学意义(F=7.19,P<0.01、Z=-3.03,P<0.01),显示该抗抑郁药物和安慰剂的疗效分布不同;8周末FBG、PBG2h测评,两组之间比较差异均有统计学意义(F值分别为4.05、4.42,P<0.05);8周末DSQL评分对比显示试验组生存质量明显提高。结论抗抑郁药物艾司西酞普兰能有效改善T2DM患者的抑郁症状、糖代谢及生存质量。

Analysis on clinical anti-depression effectiveness of escitalopram for type 2 diabetes patients

Objective .To evaluate the clinical effectiveness and safety of escitalopram in treating depression for T2DM （type 2 diabetes mellitus） patients. Methods The 71 subjects who meet the depression standard were randomized to test group and control group. All the patients were assessed with Hamilton Depression Scale before the treatment and at the second, forth and eighth weekend after the treatment respectively, and at the eighth weekend, they also had detection of serum fasting blood glucose （FBG） and post-prandial 2 hours blood glucose （PBG2h） and reassessed with DSQL. Results The HAMD assessment results： the differences between the both groups were of statistical significance （F=7.19, P〈0.01）. HAMD score decrease rate was obtained by analysis of two groups of sequenced variables through rank sum test （Z=-3.03, P〈0.01）, i.e. it could be considered that the effectiveness distribution of the anti-depression drug and that of the comforter were different. The differences of FBG and PBG2h results between the two groups at the eighth weekend were of statistical significance （F being 4.05 and 4.42 respectively,P〈0.05）. Comparison of the DSQL scores at the eighth weekend had been demonstrated significant improvement in the quality of life of the test group. Conclusion Antidepression drugs escitaloptam, can improve effectively the depression, the glucose metabolism and the quality of life of the T2DM patients with its advantages such as small dose, quick action, and little interference with other drugs, is superior in the control of depression in T2DM patients.