原发性高血压肱动脉功能与左室肥厚的相关性研究

目的 :探讨原发性高血压 (EH)患者肱动脉功能与左心室肥厚的相关性。方法 :采用超声技术分别检测2 8例 EH患者 (EH组 )和 30例正常健康者 (正常组 )肱动脉功能及左心室质量各参数 ,并进行相关性分析。结果 :EH组舒张末期肱动脉内径 (Dd)、横截面积 (L CSA)较正常组明显增加 ,顺应性系数 (CC)、肱动脉扩张系数 (DC)较正常组明显减少。相关分析结果显示 :DC、CC与血压、年龄呈负相关 (P <0 .0 1) ,L CSA与年龄、血压正相关(P<0 .0 1) ;左心室舒张末期容积指数与 L CSA正相关 (P<0 .0 1) ,与 DC负相关 (P<0 .0 1) ;平均室壁厚度与DC、CC负相关 (P<0 .0 1) ,心室质量容积比率与 DC、CC负相关 (P<0 .0 1) ,左心室质量指数与 L CSA正相关 ,与 DC负相关 (P <0 .0 1)。结论 :EH患者存在肱动脉功能的改变 ,并能影响左心室质量。

Invastigating the relationship between function of brachial artery and left ventricular hypertrophy in essestial hypertension

Objective:To determine the relationship between the function of the brachial artery and left ventricular hypertrophy in essential hypertensives. Method:Doppler ultrasound echography was used.Result:Compaired with 30 normatensives; 28 hypertensive patients had an increase in brachial artery innerdiameter(Dd)and luminal cross section area(LCSA); a decrease in artery distensibility coefficient(Dc)and compliant coefficient(CC).In multivariate analysis of the population as whole,the following relations were satistically significant: the LCSA was positively correlated to BP and age; the DC and CC were negatively correlated to BP and age;the left ventricular end diastolic volume was positively correlated to luminal cross section area and negatively to DC; the mean wall thickness was negetively correlated to DC and CC;mass volume ratio was negatively correlated to DC and CC.Left ventricular mass index was positively correlated to LCSA and negatively correlated to DC. Conclusion:It suggests that the change of brachial arterial function may effect left ventricular mass in essential hypertensives.