Changes in rat cerebral blood volume due to modulation of the 5-HT1A receptor measured with susceptibility enhanced contrast MRI |
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Authors: | B. Ellen Scanley Richard P. Kennan John C. Gore |
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Abstract: | Brain blood volume changes in the rat in response to 5-HT1A agonist and antagonist administration were measured using susceptibility contrast enhanced magnetic resonance imaging (MRI). Administration of the 5-HT1A agonist 8-OH-DPAT resulted in decreases in fractional brain blood volumes. Administration of the 5-HT1A antagonist WAY-100635 following a dose of 8-OH-DPAT resulted in increases in fractional blood volumes greatest in hippocampus and cortex and smallest in thalamus and caudate-putamen. The magnitude of the regional increases in blood volumes paralleled the distribution of 5-HT1A receptors in the rat brain. Administration of WAY-100635 alone resulted in decreases in cortical blood volume and increases in cerebellar blood volume. |
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Keywords: | 5-HT1A receptor 8-OH-DPAT WAY-100635 Cerebral blood volume MRI |
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