Neural abnormalities during cognitive generation of affect in treatment-resistant depression. |
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Authors: | Veena Kumari Martina T Mitterschiffthaler John D Teasdale Gin S Malhi Richard G Brown Vincent Giampietro Michael J Brammer Lucia Poon Andrew Simmons Steven C R Williams Stuart A Checkley Tonmoy Sharma |
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Institution: | Section of Cognitive Psychopharmacology, Institute of Psychiatry, King's College, London, UK. |
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Abstract: | BACKGROUND: Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness. METHODS: Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of affect, using a previously published paradigm of evoking affect with picture-caption pairs, in patients with unipolar, treatment-resistant depression. RESULTS: Compared with control participants, patients showed relatively decreased response in the anterior cingulate (rostral; right) with both negative and positive picture-caption pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption pairs. They demonstrated increased response in the inferior (right) and middle temporal gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus (right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right), and brain stem (left) with positive picture-caption pairs. CONCLUSIONS: Reduced medial/middle prefrontal and hippocampal activity may account for positive affect disturbances and temporal lobe hyperactivity for negative affect disturbances in treatment-resistant depression. The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and nonresponsiveness to treatment in depression. |
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Keywords: | Depression functional magnetic resonance imaging affective processing |
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