| 血浆IGFBP-2在高级别脑胶质瘤手术加放化疗前后的变化 |
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| 引用本文： | 周开甲,张鸣,刘辉,杨玉玲,王永志.血浆IGFBP-2在高级别脑胶质瘤手术加放化疗前后的变化[J].现代医药卫生,2010,26(4):481-483. |
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| 作者姓名： | 周开甲 张鸣 刘辉 杨玉玲 王永志 |
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| 作者单位： | 1. 福建省肿瘤医院头颈外科,福建,福州,350001
2. 首都医科大学附属北京天坛医院脑胶质瘤诊治中心,北京,100050 |
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| 摘 要： | 目的:探讨脑胶质瘤病人血浆类胰岛素样生长因子结合蛋白2(insulin-like growth factor binding protein 2;IGFBP-2)浓度在病情判定、预测复发中的临床意义.方法:用酶联免疫法(EUSA)对健康体检者、不同级别胶质瘤及高级别胶质瘤病人综合治疗后复发前后血浆IGFBP-2浓度进行统计学比较,随访其中55例高级别胶质瘤病人2.5年.分析术前血浆IGFBP-2浓度与其元瘤生存期关系.结果:(1)血浆IGFBP-2浓度随着胶质瘤级别的升高而增加(F=17.745,P=0.000);(2)高级别胶质细胞瘤病人经过手术、放疗、化疗综合治疗后,未复发病人血浆IGFBP-2明显下降(t=2.164,P=0.041),而复发后明显升高(t=8.295,P=0.000);(3)血浆中IGFBP-2浓度＜600 ng/ml的高级别脑胶质瘤病人的无瘤生存期明显长于浓度＜600 ng/ml的高级别脑胶质瘤病人(Z=2.272,P=0.023).结论:血浆IGFBP-2浓度的动态监测对判定胶质瘤病人病变恶性程度、预测高级别胶质瘤的复发有一定的临床意义.
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| 关 键 词： | 类胰岛素样生长因子 类胰岛素样生长因子结合蛋白质类 类胰岛素样生长因子结合蛋白质2 神经胶质瘤 |
Variation of plasma IGFBP-2 level in patients with high-grade glioma after combined therapy of operation,radiotherapy and chemotherapy |
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| ZHOU Kai-jia,ZHANG Ming,LIU Hui,et al..Variation of plasma IGFBP-2 level in patients with high-grade glioma after combined therapy of operation,radiotherapy and chemotherapy[J].Modern Medicine Health,2010,26(4):481-483. |
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| Authors: | ZHOU Kai-jia ZHANG Ming LIU Hui |
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| Institution: | ZHOU Kai-jia1,ZHANG Ming1,LIU Hui1,et al.(1.Department of Head,Neck Surgery,Fujian Provincial Tumor Hospital,Fuzhou,Fujian 350001,China,2.Diagnosis , Treatment Center of Glioma,Affiliated Tiantan Hospital,Capital Medical University,Beijing 100050,China) |
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| Abstract: | Objective:To investigate the clinical significance of detecting insulin-like growth factor binding protein 2(IGFBP-2) in plasma of the patients with glioma for judging glioma grade and predicting glioma recurrence.Methods:The plasma IGFBP-2 level was measured by enzyme linked immunosorbent assay(ELISA ) in 51 cases with WHO 2 glioma,26 cases with anaplasia glioma,56 cases with glioblastoma,30 healthy controls,and patients with high-grade glioma before and after receiving combined therapy.Meanwhile,to analys... |
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| Keywords: | Insulin-like growth factor Insulin-like growth factor binding protein Insulin-like growth factor binding protein 2 Glioma |
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