Evidence-based management of thrombosis in the antiphospholipid antibody syndrome |
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Authors: | Petri Michelle |
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Affiliation: | (1) Department of Medicine: Rheumatology, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, 21205 Baltimore, MD, USA |
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Abstract: | Recommendations for the management of thrombosis in the antiphospholipid antibody syndrome have been based largely on retrospective case series. Several clinical trials have been recently published on the management of thrombosis in general. Two clinical trials have specifically addressed thrombosis in antiphospholipid antibody syndrome, and one is underway. These new clinical trials have challenged the previous dogma of a target International Normalized Ratio of 3 to 4 (“high-intensity” warfarin). |
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