幽门螺杆菌与胃炎活动性关系的病理观察

目的:探讨胃癌高危人群幽门螺杆菌(Helicobacterpylori,Hp)与胃炎活动性的关系。方法:对胃癌高发区成年人群(533人)做内镜、快速尿素酶试验及胃粘膜活检组织学检查,Hp以组织学WS染色检查为标准,数据结果均做χ2检验。结果:(1)人群Hp的检出率为64.54%,活动性胃炎的检出率为69.42%。(2)活动性胃炎中Hp的检出率为92.43%。(3)Hp阳性组活动性胃炎的检出率为99.42%,明显高于Hp阴性组。(4)胃窦部及体小弯活动性胃炎的检出率高于胃底部;胃窦部高于体小弯。(5)Hp阳性者各活检部位的活动性胃炎组织中Hp的检出率均高。(6)Hp根除后活动性胃炎的检出率明显下降(5.77%),前后比较差异有极显著性。结论:(1)Hp与胃炎活动性密切相关。(2)Hp的检出提示胃内有活动性炎症的存在。

Pathological observation of the relation between Helicobacter pylori and activity of gastritis

Objective: To study the relation between Helicobacter pylori (Hp) in gastric cancer prevalent population and activity of gastritis. Methods:A survey was conducted on adult population in gastric cancer prevalent area. 533 individuals were subjected to gastroendoscopy. Biopsy specimens were taken to be tested by rapid urease tests and histology with w s stain positive as criterion of Hp infection. Data were treated with chi square. Results: (1) Hp infection in adults maintained 64.54% and the rate of active gastritis was 69.42%. (2) Hp infection in active gastritis was 92.43%. (3) In Hp infection cases the rate of active gastritis was 99.42%. (4) The incidence of active gastritis of antrum and lesser curvature of body were higher than that of fundus, and that of antrum higher than that of lesser of body. (5) In Hp infection cases, the detection on rate of Hp in active gastritis was high in different specimens. (6)After Hp eradication, rate of active gastritis appeared to descend (5.77%) . Conclusion:(1) Hp and the activity of gastritis had a close relation. (2) The detection of Hp suggested an active inflammation in gastric membrane.