老年脑转移瘤患者再次放疗联合替莫唑胺化疗疗效分析

目的探讨老年脑转移瘤患者再次放疗联合替莫唑胺治疗的临床疗效及安全性。方法将辽宁省肿瘤医院2009年1月至2011年12月收治52例老年脑转移瘤患者随机分为放疗组(n=24)和联合治疗组(n=28)。放疗组采用三维适形放疗,联合治疗组在放疗组基础上口服替莫唑胺治疗。治疗后对两组患者的疗效、生存质量以及不良反应情况进行评价与比较。结果联合治疗组总有效率为89.3%(25/28),放疗组为75.0%(18/24),两组间比较,差异有统计学意义(P<0.05)。联合治疗组中位生存时间为13.1个月,较放疗组(10.5个月)明显延长(P<0.05)。联合治疗组日常生活活动能力量表评分明显低于放疗组,而简易智力状态检查量表评分则显著高于放疗组(P<0.05);两组间各不良反应发生率比较,差异无统计学意义(P>0.05)。结论三维适形放疗联合替莫唑胺治疗老年脑转移瘤疗效确切,安全性好,对患者生活质量有显著提高作用。

Effect of radiotherapy combined with temozolomide on metastatic brain tumor

Objective To investigate the clinical effect and safety of radiotherapy combined with temozolomide on elderly patients with metastatic brain tumor.Methods A retrospective study was performed on 52 patients with elderly metastatic brain tumor who were admitted from January 2009 to December 2011.Patients were divided into the control group(n=24)and the combination group(n=28).Patients in the control group were treated with three-dimensional conformal radiotherapy,the patients in the combination group took oral temozolomide based on the control group.After treatment,the clinical effect,quality of life and adverse reaction of patients were evaluated.Results The total effectiveness(RR)in the combination group was 89.3%(25/28),and 75.0%(18/24)in the control group,the differences were statistically significant between the two groups(P<0.05).The ADL in the combination group was significantly lower than that in the control group,MMSE score in the combination group was significantly higher than that in the control group(P<0.05);there was no statistically significant difference of the incidence of adverse reactions between the two groups(P>0.05).Conclusion Oral Temozolomide combined with three-dimensional conformal radiotherapy for elderly brain metastases patients has better efficacy and safety,which can improve the life quality of patients.