Predictive value of excision repair cross-complementing rodent repair deficiency complementation group 1 and ovarian cancer risk

Objective: We aimed to analyze the association between excision repair cross-complementing rodent repairdeficiency complementation group 1 (XRCC1) and ovarian cancer risk. Methods: We performed a hospital-basedcase-control study with 155 cases and 313 controls in China. All Chinese cases with newly diagnosed primaryovarian cancer between May 2005 to May 2010 in our hospital were invited to participate within 2 months ofdiagnosis. Controls were randomly selected from people who requested general health examinations in the samehospital during the same period. SNPs in EXCC1, ERCC1 C8092A and ERCC1 T19007C, were analyzed byPCR-RFLP method. Results: We observed a non-significantly increased risk of ovarian cancer among individualswith ERCC1 8092TT compared with those with the 8092CC genotype (adjusted OR=1.55, 95% CI%=0.74-2.97).Moreover, 19007TT genotype carriers also showed a non-significant increased risk of ovarian cancer over thosewith the 19007CC genotype (adjusted OR=1.78, 95% CI%=0.91-3.64). Conclusion: Our firstly investigationof links between polymorphisms in the ERCC1 gene and the risk of ovarian cancer in Chinese populationdemonstrated no significant association. Further large sample studies in Chinese populations are needed.