坤泰胶囊联合枸橼酸氯米芬胶囊、戊酸雌二醇治疗排卵障碍的临床观察

目的观察坤泰胶囊联合枸橼酸氯米芬胶囊、戊酸雌二醇治疗排卵障碍的临床疗效。方法 2013年6月—2014年6月安阳市妇幼保健院收治的排卵障碍患者180例,随机分为对照组和治疗组,每组90例。对照组患者月经第5天口服枸橼酸氯米芬胶囊,2粒/次,1次/d,共5 d;同时在月经第8天口服戊酸雌二醇片,2片/次,1次/d,直到卵泡成熟。治疗组在对照组基础上从月经第5天开始口服坤泰胶囊,4粒/次,3次/d,直至卵泡成熟。两组均连续治疗3~6个月,发现妊娠后停止用药。结果治疗组成熟卵泡数目、子宫内膜厚度与对照组比较差异无统计学意义。治疗组排卵率和妊娠率均显著高于对照组,两组比较差异有统计学意义(P0.05)。结论坤泰胶囊联合枸橼酸氯米芬胶囊、戊酸雌二醇治疗排卵障碍具有较好的临床疗效,能够提高排卵率和妊娠率,值得在临床推广应用。

Clinical observation of Kuntai Capsules combined with Clomifene Citrate Capsules and estradiol valerate in treatment of ovulation disorder

Objective To explore the clinical effect of Kuntai Capsules combined with Clomifene Citrate Capsules and estradiol valerate in treatment of ovulation disorder. Methods The patients with ovulation disorder (180 cases) of Anyang Maternal and Child Health Care Centre from June 2013 to June 2014 were randomly divided into control and treatment groups, and each group has 90 cases. The patients in the control group were po administered with Clomifene Citrate Capsules from the fifth day of menstruation for 5 d, 2 capsules/time, once daily. At the same time they were po administered with Estradiol Valerate Tablets from the eighth day of menstruation until follicle was stimulating, 2 tablets/time, once daily. The patients in the treatment group were po administered with Kuntai Capsules from the fifth day of menstruation on the basis of the control group until follicle was stimulating, 4 capsules/time, three times daily. The patients in two groups were treated for 3-6 months until pregnant. Results There was no statistically significant difference between two groups about mature follicles number and endometrial thickness. The ovulation rate and pregnancy rate in the treatment group were higher than those in the control group, and there were differences between two groups (P< 0.05). Conclusions Kuntai Capsules combined with Clomifene Citrate Capsules and estradiol valerate have the good clinical effect in treatment of ovulation disorder, and can increase ovulation rate and pregnancy rate, which is worth clinical promotion.