| 肺癌组织中端粒酶活性研究 |
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| 引用本文： | 黄礼年,汪和桥. 肺癌组织中端粒酶活性研究[J]. 肿瘤防治研究, 2001, 28(1): 13-14 |
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| 作者姓名： | 黄礼年 汪和桥 |
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| 作者单位： | 1. 233004 蚌埠，安徽省肿瘤医院呼吸科
2. 太湖县人民医院 |
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| 摘 要： | 目的 探讨端粒酶作为原发性肺癌肿瘤标记物的可能性。方法 采用 TRAP法检测了 81例纤维支气管镜活检组织端粒酶活性 ,包括 50例肺癌组织 ,2 4例慢性粘膜炎组织 ,7例化生、不典型增生组织。结果 50例原发性肺癌组织中 ,有 41例端粒酶活性表达阳性 ,其阳性率为 82 % ;7例不典型增生组织中端粒酶活性表达阳性 4例 ,2 4例慢性粘膜炎标本中 ,2例端粒酶表达阳性。结论 端粒酶是一种特异性的恶性肿瘤基因标志物。
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| 关 键 词： | 肺肿瘤 端粒酶 端粒重复序列扩大技术 |
| 文章编号： | 1000-8578(2001)01-0013-02 |
| 收稿时间： | 1999-12-07 |
| 修稿时间： | 1999-12-07 |
Study of the TelomeraseActivity in Human Lung Cancer |
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| HUANG Li|nian,WANG He|qiao Auhui Tumor Hospital,Anhui ,China. Study of the TelomeraseActivity in Human Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2001, 28(1): 13-14 |
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| Authors: | HUANG Li|nian WANG He|qiao Auhui Tumor Hospital Anhui China |
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| Affiliation: | HUANG Li|nian,WANG He|qiao Auhui Tumor Hospital,Anhui 233004,China |
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| Abstract: | Objective To investigate the possibility of using telomerase as a tumor marker for human primary lung cancer.Methods 81 human lung specimens,comprising 50 carcinoma tissues,24 chronic mucitis tissues and 7 metaplasia or atypia tissues,were examined for telomerase activity by TRAP assay.Results 41 of 50 the carcinoma tissue specimens were positive for telomerase activity with a positive rate of 82%,4 of 7 atypical tissue specimens and two of 24 chronic mucitis tissue specimens were positive.Conclusion Telomerase is a tumor specific gene marker. |
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| Keywords: | Lung neoplasms Telomerase Telomeric repeat amplification protocol(TRAP) |
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