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HER2与胃癌的研究进展
引用本文:池肇春,陈爱萍. HER2与胃癌的研究进展[J]. 胃肠病学, 2014, 0(9): 573-576
作者姓名:池肇春  陈爱萍
作者单位:中国海洋大学附属医院,青岛市市立医院消化内科,266071
摘    要:本文综述了HER2与胃癌相关的研究进展,介绍了HER2的结构、相关信号途径、在胃癌中的检测方法和检出率以及人源化抗HER2单克隆抗体曲妥珠单抗与胃癌治疗、HER2与胃癌预后的关系。研究显示HER2阳性是胃癌预后不良的重要因子,曲妥珠单抗与化疗药物联合应用是HER2阳性进展期胃和胃食管连接部癌以及伴肝转移患者治疗的新选择,可明显改善患者预后。

关 键 词:HER2  胃肿瘤  曲妥珠单抗  免疫组织化学  原位杂交  预后

Progress in Research on HER2 and Gastric Cancer
CHI Zhaochun,CHEN Aiping. Progress in Research on HER2 and Gastric Cancer[J]. Chinese Journal of Gastroenterology, 2014, 0(9): 573-576
Authors:CHI Zhaochun  CHEN Aiping
Affiliation:. (Department of Gastroenterology, Qingdao Municipal Hospital, the Affiliated Hospital of Ocean University of China, Qingdao, Shandong Province 266071)
Abstract:This paper reviewed the progress in research on HER2 and gastric cancer,introducing the structure, signaling pathways,detection method and detection rate of HER2,the therapeutic effect of trastuzumab,a humanized anti-HER2 monoclonal antibody on gastric cancer,and the correlation between HER2 and prognosis of gastric cancer. Studies showed that HER2-positive was a factor with poor prognosis,and trastuzumab combined with chemotherapy was a new treatment option for patients with HER2-positive advanced gastric and gastroesophageal junction cancer or with liver metastases,which could significantly improve the prognosis.
Keywords:HER2  Stomach Neoplasms  Trastuzumab  Immunohistochemistry  In Situ Hybridization  Prognosis
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