| HER2与胃癌的研究进展 |
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| 引用本文： | 池肇春,陈爱萍.HER2与胃癌的研究进展[J].胃肠病学,2014(9):573-576. |
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| 作者姓名： | 池肇春 陈爱萍 |
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| 作者单位： | 中国海洋大学附属医院,青岛市市立医院消化内科,266071 |
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| 摘 要： | 本文综述了HER2与胃癌相关的研究进展,介绍了HER2的结构、相关信号途径、在胃癌中的检测方法和检出率以及人源化抗HER2单克隆抗体曲妥珠单抗与胃癌治疗、HER2与胃癌预后的关系。研究显示HER2阳性是胃癌预后不良的重要因子,曲妥珠单抗与化疗药物联合应用是HER2阳性进展期胃和胃食管连接部癌以及伴肝转移患者治疗的新选择,可明显改善患者预后。
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| 关 键 词： | HER2 胃肿瘤 曲妥珠单抗 免疫组织化学 原位杂交 预后 |
Progress in Research on HER2 and Gastric Cancer |
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| CHI Zhaochun,CHEN Aiping.Progress in Research on HER2 and Gastric Cancer[J].Chinese Journal of Gastroenterology,2014(9):573-576. |
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| Authors: | CHI Zhaochun CHEN Aiping |
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| Institution: | . (Department of Gastroenterology, Qingdao Municipal Hospital, the Affiliated Hospital of Ocean University of China, Qingdao, Shandong Province 266071) |
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| Abstract: | This paper reviewed the progress in research on HER2 and gastric cancer,introducing the structure, signaling pathways,detection method and detection rate of HER2,the therapeutic effect of trastuzumab,a humanized anti-HER2 monoclonal antibody on gastric cancer,and the correlation between HER2 and prognosis of gastric cancer. Studies showed that HER2-positive was a factor with poor prognosis,and trastuzumab combined with chemotherapy was a new treatment option for patients with HER2-positive advanced gastric and gastroesophageal junction cancer or with liver metastases,which could significantly improve the prognosis. |
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| Keywords: | HER2 Stomach Neoplasms Trastuzumab Immunohistochemistry In Situ Hybridization Prognosis |
| 本文献已被 CNKI 维普 等数据库收录！ |
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