冠心病患者血清白介素-6、白介素-8和肿瘤坏死因子的变化及临床意义

目的探讨冠心病患者血清炎症因子白介素-6（IL-6）、白介素-8（L-8）和肿瘤坏死因子（TNF）含量在冠心病发展过程中的意义。方法测定81例冠心病患者血清炎症因子IL-6、IL-8和TNF含量，观察冠心病患者冠脉狭窄程度与血清IL-6、IL-8及TNF含量变化的关系。结果40例冠脉重度狭窄者血清炎症因子IL-6、IL-8和TNF分别为（163．41±64．18）pg／ml、（0．41±0．11）ng／ml、（2．54±0．63）ng／ral，41例冠脉轻中度狭窄者血清炎症因子IL-6、IL-8和TNF分别为（97．05±27．29）pg／ml、（0．34±0．16）ng／ml、（1．86±0．33）ng／ml，两组间差异存在统计学意义（P〈0．05）。结论血清炎症因子IL-6、IL-8和TNF与冠心病的严重程度有关。冠脉狭窄越明显，炎症因子IL-6、IL-8及TNF含量越高。

The changes and clinical outcomes of interleukin-6,interleukin-8,tumor necrosis factor In patients with coronary heart disease

Objective To investigate the clinical significances in progress of coronary heart disease （CHD） of interleukin-6, 8（IL-6,8 ） and tumor necrosis factor（TNF） in patients with CHD. Methods The levels of IL-6,8 and TNF in 81 patiems with CHD were measured, and then analyzed their relationship with the degree of coronary artery stenosis. Results The levels of IL-6,8 and TNF in 40 patients with severe degree of coronary artery stenosis were （ 163.41 ±64.18 ）pg/ml, （0.41 ±0.11 ）ng/ml, and （2.54±0.63）ng/ml, and in the 41 patients with middle and mild coronary artery stenosis were （97.05±27.29）pg/ml, （0.34±0.16）ng/m1, and （1.86±0.33）ng/ml. The levels of IL-6,8 and TNF in patients with severe degree of coronary artery stenosis were significandy higher than that of middle and mild group（P〈0.05）. Conclusion The inflammatory factor of IL-6,8 and TNF are correlate with the degree of coronary artery stenosis. The higher the degree of coronary artery stenosis is, the higher levels of interleukin-6,8 and TNF are.