Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms |
| |
Authors: | Lin Zhi-bin Zhang Hui-na |
| |
Affiliation: | DepartmentofPharmacology,SchoolofBasicMedicalSciences,PekingUniversityHealthScienceCenter,Beijing100083,China |
| |
Abstract: | Ganoderma lucidum (G lucidum) is a medicinal fungus with a variety of biological activities. It has long been used as a folk remedy for promotion of health and longevity in China and other oriental countries. The most attractive character of this kind of medicinal fungus is its immunomodulatory and anti-tumor activities. Large numbers of studies have shown that G lucidum modulate many components of the immune system such as the antigen-presenting cells, NK cells, T and B lymphocytes. The water extract and the polysaccharides fraction of G lucidum exhibited significant anti-tumor effect in several tumor-bearing animals mainly through its immunoenhancing activity. Recent studies also showed that the alcohol extract or the triterpene fraction of G lucidum possessed antitumor effect, which seemed to be related to the cytotoxic activity against tumor cells directly. Preliminary study indicated that antiangiogenic effect may be involved antitumor activity of G lucidum. |
| |
Keywords: | Ganoderma lucidum polysaccharides triterpene immunomodulatory activities anti-tumor activities |
本文献已被 CNKI 维普 PubMed 等数据库收录! |
|