Association of natural killer cell immune recovery with a graft-versus-leukemia effect independent of graft-versus-host disease following allogeneic bone marrow transplantation |
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Authors: | Y Z Jiang A J Barrett J M Goldman D A Mavroudis |
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Institution: | (1) Bone Marrow Transplantation Unit, Hematology Branch, Building 10, Room 7c-103, NIH, 9000 Rockville Pike, Bethesda, MD 20892-1652, USA, US;(2) Department of Hematology, Royal Postgraduate Medical School, London, United Kingdom, GB |
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Abstract: | There is good evidence that T lymphocytes play an important role in the graft-versus-leukemia (GVL) effect following allogeneic
bone marrow transplantation (BMT) for hematologic malignancies. However, the role of natural killer (NK) cells in GVL is less
clear. To further investigate a possible association of NK cells with GVL we studied 15 patients undergoing BMT for chronic
myeloid leukemia (CML), correlating T-cell (CD4+ and CD8+) and NK-cell (CD16+56+) recovery with relapse and graft-versus-host
disease (GVHD). Patients were studied on three occasions up to 9 months after BMT, for lymphocyte surface phenotype and for
spontaneous and IL-2-stimulated (LAK cell) cytotoxic function. Circulating CD8+ and NK but not CD4+ cell numbers were significantly
lower in five patients who relapsed compared with those remaining in remission after BMT (mean 0.03 vs 0.32×109/l, p=0.002 for CD8+ cells; mean 0.03 vs 0.11×109/l, p=0.002 for NK cells). There was no correlation of CD4+, CD8+, or NK cell numbers and development of grade-II or more acute
GVHD. Spontaneous NK cytotoxic function rose to within the normal range in the first month after BMT. LAK function remained
low during the study period. These results link NK cell recovery more closely with a GVL than with a GVH effect.
Received: 1 May 1996/Accepted: 19 September 1996 |
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Keywords: | Graft-vs-leukemia (GVL) Graft-vs-host disease (GVHD) Bone marrow transplantation (BMT) NK cells CD4 cells CD8 cells Immune recovery Chronic myeloid leukemia (CML) |
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