Understanding the radiolabelling mechanism of Tc–antimony sulphide colloid |
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Authors: | Chris Tsopelas |
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Institution: | RAH Radiopharmacy, Nuclear Medicine Department, Royal Adelaide Hospital, North Terrace, Adelaide 5000, Australia |
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Abstract: | The chemistry of antimony trisulphide colloid (ATC) was examined to elucidate the radiolabelling mechanism with 99mTcO4−. Ion exchange chromatography and atomic absorption spectrophotometry techniques determined ATC to be resistant to hydrolysis in 0.1 M hydrochloric acid (HCl) at 25°C or 100°C (>97% recovery, Sb3+ absent). Hydrogen sulphide gas detected did not participate in the mechanism, where antimony trisulphide and 99mTcO4− in HCl/100°C yielded 96% 99mTc-product from a K2S-free formulation (versus 98% when K2S was present). 99mTcO4− was reduced >90% by DMSA or dithiothreitol under the same conditions, identifying involvement of thiol groups. Infrared analysis of Re-ATC showed S=O bonds, indicating excess thiol groups at the colloid surface were oxidised at the expense of 99mTcO4− reduction. |
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Keywords: | Technetium-99mchemistry Technetium-99mpertechnetate reduction Antimony trisulphide colloid Lymphoscintigraphic agent |
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