CD15抗原和bcl-2基因蛋白在甲状腺癌中的表达及相关性研究

目的 研究甲状腺癌组织中ＣＤ１５抗原和ｂｃｌ－２基因蛋白的表达与肿瘤发生和转移的关系，并探讨ＣＤ１５与ｂｃｌ－２基因蛋白表达的关系。方法 应用微波－ＬＳＡＢ免疫组织化学法检测５０例甲状腺癌、４５例甲状腺腺瘤和２０例癌旁正常甲状腺组织中ＣＤ１５和ｂｃｌ－２基因蛋白表达。结果 在甲状腺癌组织中ＣＤ１５和ｂｃｌ－２基因蛋白表达阳性率分别为６８．０％和４６．０％，均显著高于甲状腺腺瘤和癌旁正常甲状腺组织（

RELATIONSHIP BETWEEN CD15 ANTIGEN AND ONCOPROTEIN BCL-2 EXPRESSION IN THYROID CANCER

Objective The expression of CD15 antigen and oncoprotein bcl 2 in thyroid cancer were examined in order to study the correlation between them. Methods The expression of CD15 and bcl 2 in 50 thyroid cancers, 20 adjacent noncancerous portion, 45 adenoma and 10 normal thyroid tissue were respectively investigated by microwave LSAB immunohistochemical technique. Results The positive rate of CD15 and bcl 2 in thyroid cancer was 68.0% and 46.0% respectively, which was significantly higher than that in adenoma or adjacent noncancerous ( P <0.05). The percentage of CD15 and bcl 2 positive expression were found to be significantly correlated with the tumor metastasis ( P <0.05), but not correlated with histological feature. Expression of CD15 was significantly correlated with bcl 2. Conclusion Expression of CD15 and bcl 2 can be regarded as a parameter to evaluate tumor metastasis and prognosis of thyroid cancer.