灯盏细辛注射液体外抗菌作用及其无菌检查

目的探讨灯盏细辛注射液体外抗菌活性及其无菌检查方法.方法应用三种药物体外抗菌、抑菌实验方法,检查灯盏细辛注射液体外抗菌作用并初步确定其无菌检查方法;通过无菌验证实验方法来确定其无菌检查方法的有效性.结果灯盏细辛注射液的直接接种法无菌检查法抑菌实验显示其对金黄色葡萄球菌的强大抑制作用,直接接种法不能用于其无菌检查;进一步体外抗菌、抑菌实验显示其体外具有较强的抗菌、抑菌作用;应用薄膜过滤法对其无菌项目进行检查,无菌验证实验确定其无菌检查的有效方法为薄膜过滤法.结论灯盏细辛注射液体外对金黄色葡萄球菌的显示出强大的抑制作用,其无菌检查的有效方法为薄膜过滤法.

Antibacterial effect in vitro of injection of Erigeron brevisca Pus and its sterility test

Objective To determine antibacterial effect in vitro of injection of Erigeron brevisca Pus and its sterility test. Methods The methods of antibacte rial effects in vitro was used to investigate the antibacterial effect of inject ion of Erigeron brevisca Pus,and the method of sterility was established by a validiation test. Results Injection of Erigeron brevisca Pu s showed strong bacteriostasis effect in vitro , as a result,direct inoculatio n method isn't fit for its sterility test,membrane filtration method was the val idatory method of its sterility test. Conclusion Injection of Erigeron brevisca Pus has strong bacteriostasis effects in vitro,the suitab le method of its sterility test is membrane filtration method.