鸦胆子油自微乳的体外释放度考察

目的:建立鸦胆子油自微乳溶出度的测定方法.方法:采用气相色谱法测定鸦胆子油中油酸的含量,以确定鸦胆子油自微乳化制剂溶出度测定的最佳条件.色谱条件为DB-FFAP毛细管柱(0.25 mm ×30 m,0.25 μm),进样口温度220℃,检测器温度220℃,柱温205℃,进样量1 μL.以0.1 mol·L-1HCI为溶出介质,硬胶囊壳为载体,转篮法测定鸦胆子油自微乳化给药系统的体外溶出度.结果:鸦胆子油自微乳累积溶出度在15 min达90％.结论:该测定方法准确可靠,可用于鸦胆子油自微乳的质量控制.

Investigation of in vitro Release Rate of Brucea javanica Oil Self-microemulsion

Objective:To establish determination method of in virto release of Brucea javanica oil self-microemulsion.Method: The content of oleic acid from B.javanica oil was determined by GC method,to determine optimum conditions of dissolution determination of B.javanica oil self-microemulsion.Chromatographic conditions were:DB-FFAP capillary column(0.25 mm×30 m,0.25 μm),column temperature of 205 ℃,temperture of inlet and detector were 220 ℃,sample volume 1 μL.0.1 mol·L-1 HCl as dissolution medium,hard capsule shell as a carrier,in vitro release of B.javanica oil self-microemulsion drug delivery system was determined by rotating basket method.Result: Cumulative dissolution of B.javanica oil self-microemulsion was 90% in 15 min.Conclusion: This determination method was accurate and reliable,and it could be used for quality control of B.javanica oil self-microemulsion.