| 陡脉冲电场对荷瘤BALB/C小鼠生存期的影响 |
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| 引用本文： | 姚陈果,孙才新,熊兰,米彦,廖瑞金,胡丽娜,胡娅. 陡脉冲电场对荷瘤BALB/C小鼠生存期的影响[J]. 生物医学工程学杂志, 2004, 21(3): 433-435 |
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| 作者姓名： | 姚陈果 孙才新 熊兰 米彦 廖瑞金 胡丽娜 胡娅 |
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| 作者单位： | 1. 重庆大学,高电压与电工新技术教育部重点实验室,重庆,400044
2. 重庆医科大学,附属第二医院,重庆,400061 |
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| 基金项目： | 国家自然科学基金资助项目 ( 5 0 0 770 2 7) |
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| 摘 要： | 观测陡脉冲对荷瘤 BAL B/ C小鼠癌细胞的杀伤效应和抑制作用。抑瘤观察中发现治疗组小鼠肿瘤体积明显减小 ,肿瘤生长受到抑制 ,治疗组和对照组间差异有显著性 ;生存期观察中发现经陡脉冲治疗后的荷瘤小鼠生存期明显延长。实验揭示了陡脉冲能有效地杀伤癌细胞 ,明显抑制了荷瘤小鼠恶性肿瘤的生长、增殖 ,有着良好的应用前景
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| 关 键 词： | 陡脉冲电场 癌细胞 不可逆性电击穿 生存 |
Effect of Steep Pulsed Electric Fields on Survival of Tumour-bearing Mice |
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| Yao Chenguo Sun Caixin Xiong Lan Mi Yan Liao Ruijin Hu Lina Hu Ya. Effect of Steep Pulsed Electric Fields on Survival of Tumour-bearing Mice[J]. Journal of biomedical engineering, 2004, 21(3): 433-435 |
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| Authors: | Yao Chenguo Sun Caixin Xiong Lan Mi Yan Liao Ruijin Hu Lina Hu Ya |
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| Affiliation: | College of Electrical Engineering, Chongqing University, Chongqing, 400044, China. |
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| Abstract: | To investigate the lethal effect of steep pulsed electric fields (SPEFs) on cancer cells and the life-prolonging effect of SPEFs on the survival of tumour-bearing mice, this study was carried out with the use of SPEFs to treat 40 BALB/C mice inoculated by cervical cancer.The lethal effect on cancer cells and the life-prolonging effect on tumour-bearing mice were examined and compared between the experiment group and control group. The survival periods of the experiment group and control group were 52.05 days and 33.03 days, respectively. There was a significant difference in survival curve between the two groups. The results confirmed the inhibitiory effect and lethal effect of SPEFs on cancer cells. SPEFs can prolong the survival period of tumour-bearing mice. |
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| Keywords: | Steep pulsed electric fields (SPEFs) Cancer cells Irreversible electrical breakdown (IREB) Survival |
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