| HIV高度暴露血清学指标持续阴性者的流行病学调查和HLA分型研究 |
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| 引用本文： | 徐克沂,董涛,伦文辉. HIV高度暴露血清学指标持续阴性者的流行病学调查和HLA分型研究[J]. 中华实验和临床病毒学杂志, 2006, 20(2): 72-74 |
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| 作者姓名： | 徐克沂 董涛 伦文辉 |
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| 作者单位： | 1. 100011,北京,北京地坛医院
2. 英国牛津大学 |
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| 摘 要： | 目的 了解中国有偿献血人群中的HIV高度暴露血清学指标持续阴性者（highlyexposed but persistently seronegative,HEPS）流行病学和HLA分型情况.方法 采用队列研究方法对有偿献血人群进行流行病学追踪、血清流行病学调查研究.利用序列特异性引物PCR（PCR with sequencespecific primer,PCR-SSP）进行HLA分型.结果 流行病学研究发现8例HIV高度暴露血清学指标持续阴性者,HLA分型HEPS人群与HIV抗体阳性配偶比较,HLA-A24、HLA-40基因型占优势.结论 在中国有偿献血人群中存在HIV高度暴露血清学指标持续阴性者,初步分析中国HEPS人群HLA分型,结 HLA-A24、HLA-B40基因型占优势.
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| 关 键 词： | HIV 艾滋病血清学诊断 HLA抗原 |
| 收稿时间： | 2005-05-16 |
| 修稿时间： | 2005-05-16 |
Epidemiologic study and HLA analysis of highly exposed to HIV but persistently seronegative subjects (HEPS) in commercial blood donors in China |
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| XU Ke-yi,DONG Tao,LUN Wen-hui. Epidemiologic study and HLA analysis of highly exposed to HIV but persistently seronegative subjects (HEPS) in commercial blood donors in China[J]. Chinese journal of experimental and clinical virology, 2006, 20(2): 72-74 |
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| Authors: | XU Ke-yi DONG Tao LUN Wen-hui |
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| Affiliation: | Beijing Ditan Hospital, Beijing 100011, China |
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| Abstract: | Objective To investigate epidemiology and HLA typing of highly exposed to HIV but persistently seronegative subjects (HEPS) in commercial blood donors in China. Method This was a cohort study for epidemiologic characteristics of highly exposed but persistently seronegative subjects. PCR with sequence-specific primer and PCR-SSP for HLA typing were applied.Result Eight HEPS were identified. Compared HLA typing with seropositive couple,high frequency of HLA-A24,HLA-B40 genotyping was observed.Conclusions Highly exposed to HIV but persistently seronegative subjects in commercial blood donors in China had high frequency of HLA-A24 and HLA-B40 genotype. |
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| Keywords: | HIV AIDS serodiagnosis HLA antigens |
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