1998～2005年台州市高中毕业生乙肝表面抗原检测结果分析

目的了解高中毕业生HBsAg感染情况,为制定乙肝防治对策,保护学生身体健康提供科学依据。方法采用ELISA法对1998￣2005年期间台州市201483名高中毕业生进行血清HBsAg和ALT检测,对结果进行统计分析。结果高中毕业生HBsAg平均阳性率为11.28%,高于全国普通人群平均水平;HBsAg阳性率最高的是1998年为13.81%,后逐年下降,2005年最低为9.66%;男生显著高于女生(P市(11.36%)>区(8.44%),差异有统计学意义(P<0.01)。结论中学生HBsAg感染率呈逐年下降趋势。加强对新生儿和易感人群的乙肝疫苗接种工作,提高免疫覆盖率和人群免疫水平,是降低HBV感染的有效途径。

Analysis of test results of HBsAg among senior high school graduates in Taizhou city from 1998 to 2005

Objective The investigation was conducted to understand HBsAg infection among senior high school graduates and provide a scientific basis for constituting strategies against Hepatitis B to protect students' health. Methods Serum HBsAg and ALT were detected by ELISA (Enzyme-Linked ImmunosorbentAssay) among 201 483 senior high school graduates from 1998 to 2005 in the city of Taizhou,and the results were statistically analyzed. Results The mean positive rate of HBsAg was11.28 % among senior high school graduates, higher than the average positive rate in general population. It was found that positive rate of HBsAg was highest in 1998 (13.81%),and decreased year by year thereafter, with the rate being lowest in 2005(9.66%).The rate was significantly higher among boys than among girls(P<0.01). There was a significant difference in distribution in areas (P<0.01)with the rate being higher in counties(13.33%)than in the city(11.36%)and lowest in districts (8.44%).Conclusion It is seen that HBsAg infection rate among high school students takes on a trend of decreasing year by year. Strengthening inoculation of Hepatitis B vaccine among newborns and susceptible population to improve immunization coverage rate and population immunization level is an effective approach to the reduction of HBV infection.