脑梗死与血小板膜表面P-选择素及纤维蛋白原的生物表达

目的探讨脑梗死急性期血小板活化在血栓形成中的作用。方法采用流式细胞术检测脑梗死患者全血标本血小板膜表面P选择素（CD62P）与纤维蛋白受体（FIB-R）的生物表达。结果与正常对照组比较，脑梗死组（43例）及腔隙性脑梗死组（47例）于发病1～3d内CD62P与FIBR的表达（阳性细胞百分率）均有显著增高（P〈0．05或P〈0．001）。脑梗死组的FIBR表达增加明显高于腔隙性梗死组（P〈0．001），至病程第7日FIB-R表达显著高于病程1～3d，差异有显著性（P〈0．001）。两组患者中发病前服用阿司匹林与否对检测结果无显著影响。结论脑梗死与腔隙性梗死急性期均存在血小板活化；阿司匹林对血小板膜表面表达CD62P及FIBR无影响。

Biological expression of platele CD62P and FIB-R in cerebral infarction

Objective To observe the status of platelets activation in cerebral infarction.Methods Flow cytometric immunofluorescence was used to check the molecular marker,the fibrinogen receptor(FIB-R) and P-selectin(CD62P) of circulating activated platelets in patients with acute cerebral infarction.Results Compared with normal control group,both the expressions of FIB-R and CD62P were singnificantly increased in patients with cerebral infarcton(n=43) and in patients with larcunar infarction(n=47).The expression of FIB-R in patients with cerebral infarcton was more common than that in patients with larcunar infarction,and the expression level remained high in the 7th day after the attack.There was no difference observed in platelet activation between the patients with or without oral aspirin prior to the attack.Conclusion Both CD62P and FIB-R are sensitve markers for detecting circulating activated platelets.Activated platelets exist in cerebral infarcton and larcunar infarction as well.