组织纤溶酶原激活剂、肝素抑制人工晶体表面细胞学反应的实验对比研究

目的：探讨ｔＰＡ（组织纤溶酶原激活剂）、肝素对人工晶体（ＩＯＬ）表面细胞学反应的抑制作用。方法新西兰大白兔３６只，分别ｔＰＡ、肝素及对照共三组，作晶体囊外摘除及人工晶体植入术。术中分别应用含ｔＰＡ（２５μｇ／０．２ｍｌ）、肝素（１００ＩＵ／ｍｌ）和平衡盐溶液的灌注液。术后１、３、７天和１月各时段取出人工晶体，光学显微镜下观察人工晶体表面的细胞学反应情况，用ＳＡＳ软件包行方差分析。结果ｔＰＡ和肝素组

Experimental Contrast Study of Inhibiting Effects of Tpa VS Heparin on Cellular Response on Intraocular Lens Surface Following Surgery

Objective:To investigate the inhibiting effect of tPA (tissue - type plasminogen activator )and heparin on cellular response on the Intraocular Lens (IOL) surface follwing surgery, Methods: 36 New Zealand white rabbits were divided into 3 groups (the tPA, the heparin and the control group), and tPA solution(25ug/0. 2ml)and heparin solution (100U/ml )were locally applied separately during the lens extraction and IOL implantation surgery. The implanted IOLs were extracted from the rabbits' eyes on 1, 3, 7 days and 1 month after surgery, and the cellular response on the IOLs surface was observed under the light microscope. Using SAS software, variance analysis of the data was performed. Results:The degree of the cellular response on the IOLs surface in both tPA group and heparin group was lower than that in the control group, but there was no statistical difference betwween the tPA group and the heparin group. Conclusion: Both tPA and heparin have inhibiting effects on the cellular response on the IOLs surcface following operation in rabbits.