| 妊娠合并系统性红斑狼疮的临床分析 |
| |
| 引用本文： | 吴新华,左晓霞,伍招娣,张卫社,扶琼. 妊娠合并系统性红斑狼疮的临床分析[J]. 中南大学学报(医学版), 2006, 31(2): 271-273 |
| |
| 作者姓名： | 吴新华 左晓霞 伍招娣 张卫社 扶琼 |
| |
| 作者单位： | 中南大学湘雅医院,妇产科,长沙,410008;中南大学湘雅医院,风湿科,长沙,410008 |
| |
| 摘 要： | 目的：探讨妊娠与系统性红斑狼疮（SLE）病情的相互影响及SLE患者妊娠时机的选择及妊娠期的处理。方法：回顾性调查我院收治的31例妊娠合并SLE患者，其中选择性妊娠18例，非选择性妊娠13例，妊娠期予不同剂量泼尼松控制病情。分析比较2组患者妊娠期病情的变化和妊娠的结局。结果：选择性妊娠组中6例在孕期出现狼疮活动，非选择性妊娠组的13例均出现较为严重的狼疮并发症。非选择性妊娠组的妊娠丢失率、早产率较选择性妊娠组显著增高（P〈0．05），而新生儿存活率及新生儿体质量则较选择性妊娠组显著下降（P〈0．05）。结论：对妊娠合并SLE患者而言，妊娠和SLE互为不利因素；在SLE病情缓解期选择妊娠并合理治疗将使母婴安全性明显增高。
|
| 关 键 词： | 妊娠 系统性红斑狼疮 治疗 |
| 文章编号： | 1672-7347（2006）02-0271-03 |
| 收稿时间： | 2005-09-06 |
| 修稿时间： | 2005-09-06 |
|
| |
| WU Xin-hua,ZUO Xiao-xia,WU Zhao-di,ZHANG Wei-she,FU Qiong.
|
| |
| Authors: | WU Xin-hua ZUO Xiao-xia WU Zhao-di ZHANG Wei-she FU Qiong |
| |
| Affiliation: | Department of Obstetrics, Xiangya Hospital, Central South University, Changsha, China. |
| |
| Abstract: | Objective To investigate the interacting effects between pregnancy and flares of systemic lupus erythematosus(SLE) and to explore the best occasion for SLE patients' conception and the management during the pregnancy.Methods Thirty one cases of pregnancy complicated with SLE were investigated retrospectively,among whom 18 were in remission of SLE at the beginning of conception(Group A),and the other 13 either had high-activity of the disease or were first diagnosed as SLE during the pregnancy(Group B).Various doses of prednisone were administered to control SLE.Results SLE flares still occurred in 6 cases in Group A,but in all cases in Group B.Compared with Group A,the rates of fetal loss and early delivery were significantly higher in Group B(P<0.05),while the survival rate and the weight of the new born were notably decreased in Group B(P<0.05).Conclusion Pregnancy and SLE interacted with each other unfavorably.Selection of remission stage for conception and proper management during the pregnancy could significantly improve the maternal-fetal safety. |
| |
| Keywords: | pregnancy systemic lupus erythematosus(SLE) therapy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中南大学学报(医学版)》浏览原始摘要信息 |
|
点击此处可从《中南大学学报(医学版)》下载全文 |
|
