慢性细菌性前列腺炎的抗菌药物治疗

慢性细菌性前列腺炎的治疗已经成为临床医生一个极为棘手的问题 ,因为大多数抗生素很难渗透到前列腺液和组织。在临床治疗方面 ,医生应该了解抗菌药物的性能 ,包括它们的pKa值、两性离子、脂溶性和弱碱性。同其他慢性感染性疾病一样 ,慢性细菌性前列腺炎治疗时间的长短也成为一个关键点 ,一般推荐最短治疗时间应在 4周左右 ,治疗慢性细菌性前列腺炎最好的抗菌药物应是氟喹诺酮类 ,因为它是酸碱兼性药物或两性离子型药物。或选择具有广谱抗菌活性的抗生素

Antimicrobials for Chronic Bacterial Prostatitis

Treatment of chronic bacterial prostatitis (CBP) has always been a troublesome problem in clinicians, because of most antimicrobials diffuse poorly into prostatic fluid and tissues. In clinical treatment, characteristic of the drugs, including their pKa value, zwitterion, lipid soluble, a weak base, should be considered by doctors. As with other chronic infected diseases the therapeutic course of chronic bacterial prostatitis become also a key point. It is, in general, recommend that the minimun course of treatment should be persisted about 4 weeks. One of best antimicrobials for the chronic bacterial prostatitis should be fluoroquinolones because they are amphotericion or zwitterion drugs. In addition, some antibiotics of a broad spectrum with activity against the most probable pathogens should be chosen to treat CBP.