老年原发性高血压患者血压晨峰现象与靶器官损害的相关性研究

目的:探讨老年原发性高血压患者血压晨峰(MBPS)与靶器官损害的相关性。方法:老年原发性高血压患者292例,据24h动态血压分晨峰组(MBPS组,128例)与非晨峰组(非MBPS组,164例),检查血脂、空腹血糖、肌酐,计算人体质量指数(BMI)、行心脏和颈动脉超声检查,计算左室质量指数(LVMI)、颈动脉内膜中层厚度(IMT)。结果:与非MBPS组比较,MBPS组24h收缩压(SBP)(138.2±13.2)mmHg比(153.1±12.1)mmHg]、白昼SBP(143.3±12.7)mmHg比(158.2±9.1)mmHg]以及夜间SBP(136.6±9.4)mmHg比(150.7±10.1)mmHg]均明显升高(P<0.05),LVMI(101.76±34.45)g/m2比(138.13±37.6)g/m2]、颈动脉IMT(0.84±0.11)mm比(1.35±0.35)mm]均明显增大(P<0.05);Pearson相关分析显示,血压晨峰与LVMI、IMT呈正相关(r分别=0.688,0.524,P均<0.05)。结论:老年原发性高血压患者血压晨峰现象加重靶器官损害。

Correlation between morning blood pressure surge and target organ damage in aged patients with essential hypertension

Objective：To explore the correlation between morning blood pressure surge（MBPS）and target organ damage（TOD）in aged patients with essential hypertension（EH）.Methods：According to 24hambulatory blood pressure,a total of 292aged EH patients were divided into MBPS group（n=128）and non-MBPS group（n=164）.Blood lipids,fasting blood glucose,creatinine were measured and body mass index（BMI）was calculated.Heart and carotid ultrasonography were performed,and left ventricular mass index（LVMI）and carotid intima-media thickness（IMT）were calculated.Results：Compared with non-MBPS group,there were significant increase in 24hsystolic blood pressure（SBP）（138.2±13.2）mmHg vs.（153.1±12.1）mmHg],daytime SBP（143.3±12.7）mmHg vs.（158.2±9.1）mmHg],night SBP（136.6±9.4）mmHg vs.（150.7±10.1）mmHg],LVMI（101.76±34.45）g/ m2 vs.（138.13±37.6）g/m2]and carotid IMT（0.84±0.11）mm vs.（1.35±0.35）mm]in MBPS group,P＆lt; 0.05all;Pearson correlation analysis indicated that MBPS was positively correlated with LVMI and IMT（r= 0.688,0.524,P＆lt;0.05both）.Conclusion：Morning blood pressure surge could aggravate target organ damage in aged patients with essential hypertension.