血清胰淀素、ADMA水平与代谢综合征的相关性

测定代谢综合征（MS）患者血清胰淀素和非对称二甲醛精氨酸（ADMA）水平,探讨两者的相关性及二者对MS的影响。方法：70例患者和体检对象根据其存在MS组分的个数分为非MS组（MS组分0~1个,20例）、MS高危组（MS组分2个,23例）和MS组（MS组分〉2个,27例）。分别测定空腹血糖、血脂、胰岛素、腰臀比（WHR）、体重指数（BMI）等指标,同时测定血清胰淀素、ADMA的水平。结果：与非MS组比较,MS高危组,MS组血清胰淀素（0.41±0.04）g/L比（0.46±0.06）g/L比（0.49±0.06）g/L]、ADMA（1.28±0.06）μg/L比（1.46±0.07）μg/L比（1.51±0.08）μg/L]的水平明显升高（P〈0.05）,且MS组明显高于MS高危组（P均〈0.05）。Pearson相关分析表明,血清胰淀素与甘油三酯（TG）、空腹胰岛素（FINS）、BMI、WHR、胰岛素抵抗指数（IRI）、ADMA呈正相关性（r=0.441~0.563,P均〈0.05）;与高密度脂蛋白胆固醇（HDL-C）呈负相关（r=-0.461,P〈0.05）;ADMA与IRI、BMI、FINS呈正相关（r=0.445~0.483,P〈0.05）。Logistic回归分析显示胰淀素、BMI、ADMA、IRI是MS的独立危险因素（OR=5.573~7.169,P均〈0.05）。结论：血清胰淀素和非对称二甲醛精氨酸的表达与代谢综合征的发生有关,两者都是MS的独立危险因素。

Correlation among serum levels of amylin,ADMA and metabolic syndrome

Objective：To examine levels of serum amylin and asymmetric dimethylarginine（ADMA）in patients with metabolic syndrome（MS）,explore their correlation related with MS.Methods：According to number of MS components,a total of 70subjects were divided into non-MS group（MS components 0-1,n=20）,MS high risk group（MS components 2,n=23）and MS group（MS components＆gt;2,n=27）.Fasting plasma glucose,blood lipid,insulin,waist hip ratio（WHR）,body mass index（BMI）,serum levels of amylin and ADMA were measured.Results： Compared with non-MS group,there were significant increase in serum levels of amylin（0.41±0.04）g/L vs.（0.46±0.06）g/L vs.（0.49±0.06）g/L]and ADMA（1.28±0.06）μg/L vs.（1.46±0.07）μg/L vs.（1.51± 0.08）μg/L]in MS high risk group and MS group,P＆lt;0.05,and those of MS group were significantly higher than those of MS high risk group,P＆lt;0.05both.Pearson correlation analysis indicated that serum amylin was positively correlated with triglyceride（TG）,fasting insulin（FINS）,BMI,WHR,insulin resistance index（IRI）and ADMA（r=0.441~0.563,P＆lt;0.05all）;and negatively correlated with high density lipoprotein cholesterol（HDL-C）（r =-0.461,P＆lt;0.05）;ADMA was positively correlated with IRI,BMI and FINS（r=0.445~0.483,P＆lt;0.05）.Logistic regression analysis indicated that amylin,BMI,ADMA and IRI were independent risk factors of MS（OR= 5.573~7.169,P＆lt;0.05all）.Conclusion：Levels of serum amylin and asymmetric dimethylarginine are related to occurrence of metabolic syndrome,both of them may be independent risk factors of MS.