Acute phosphodiesterase 5 inhibition mimics hemodynamic effects of B-type natriuretic peptide and potentiates B-type natriuretic peptide effects in failing but not normal canine heart |
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| Authors: | Forfia Paul R Lee Myung Tunin Richard S Mahmud Mobusher Champion Hunter C Kass David A |
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| Affiliation: | Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA. |
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| Abstract: | |
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| Keywords: | ANP, atrial natriuretic peptide BNP, B-type natriuretic peptide cGMP, cyclic guanosine monophosphate dPAP, diastolic pulmonary artery pressure HF, heart failure LV, left ventricle/ventricular LVEF, left ventricular ejection fraction mPAP, mean pulmonary artery pressure NP, natriuretic peptide PDE5, phosphodiesterase type-5 SIL, sildenafil SV, stroke volume |
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