免疫RNA与正常RNA治疗30例慢性乙型肝炎的效果对比观察

HB是一种免疫失调疾病,因此,用特异性和非特异性免疫调节剂治疗是合理的。本文采用双盲法,用免疫RNA和正常RNA对30病HB病人进行了同步性的疗效对比观察。经1-2疗程旨,免疫RNA组自觉症状减轻和肝功能明显改善,细胞免疫功能增强,HBsAg阴转率27％,滴度下降者13.3％,HBeAg阴转40％,并能明显增加外周血白细胞和血小板,治愈率67％,总有效率80％。正常RNA组的HBsAg阴转率27％,HBeAg阴转0％,治愈率20％,总有效率53％。结果显示,特异性HBsAg-iRNA组治疗效果明显优于非特异性正常RNA组。

COMPARISON OF THE EFFECTIVENESS OF IMMUNE RNA AND NORMAL RNA THERAPY IN 30 PATIEENTS WITH HEPATITIS B

In this paper the effectiveness of the therapy (IRNA and normal RNA) on 30 cases with HB is reported.After 1 to 2 courses of treatment (about 90 to 180 days), the significant improvements in symptoms subsided, liver function and cellular immunity were evident in patients receiving IRNA as compared with patient receiving a normal RNA (n-RNA). 40% of HBsAg and 40% of HBeAg turned to negative, with increases in peripheral blood leukoeytes and platelete counts, altogether, the effectiveness of iRNA therapy attained 80%. Wherease 27% of HBsAg and 0% of HBeAg turned to negative in the patients receiving n-RNA, effectiveness rate being 53%.