Clinical characteristics and outcomes of COVID-19 infected diabetic patients admitted in ICUs of the southern region of Bangladesh |
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Authors: | Ayan Saha Mohammed Moinul Ahsan Md Tarek-Ul Quader Sabekun Naher Farhana Akter HM Hamidullah Mehedi ASM Arman Ullah Chowdhury Md Hasanul Karim Tazrina Rahman Ayesha Parvin |
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Institution: | 1. Children’s Cancer Institute, Faculty of Medicine, University of New South Wales, Australia;2. Intensive Care Unit, 250 Bedded General Hospital, Chattogram, 4000, Bangladesh;3. Department of Anesthesiology and Intensive Care Unit, Chittagong Medical College, Chattogram, 4202, Bangladesh;4. Department of Microbiology, University of Chittagong, Chattogram, 4202, Bangladesh;5. Department of Endocrinology, Chittagong Medical College, Chattogram, 4202, Bangladesh;6. Department of Medicine, 250 Bedded General Hospital, Chattogram, 4000, Bangladesh;7. Department of Microbiology and Virology, Chittagong Medical College, Chattogram, 4202, Bangladesh;8. Department of Biochemistry, Chittagong Medical College, Chattogram, 4202, Bangladesh;9. Disease Biology and Molecular Epidemiology Research Group, Chattogram, 4000, Bangladesh |
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Abstract: | Background and aimsDiabetes mellitus is highly prevalent among critical cases of coronavirus disease 2019 (COVID-19) with poor outcomes. This study aimed to describe the clinical characteristics and outcomes of COVID-19 patients with diabetes, admitted in the intensive care unit (ICU) of the southern region of Bangladesh.MethodsEpidemiological, clinical, laboratory, treatments, complications, and clinical outcomes data were extracted from electronic medical records of 168 COVID-19 patients admitted into ICU of two COVID-19 dedicated hospitals of Chattogram, Bangladesh and compared between diabetes (n = 88) and non-diabetes (n = 80) groups.ResultsThe prevalence of diabetes was high among 51–70 years old patients. All the diabetic patients had at least one other comorbidity, with a significantly higher incidence of hypertension (53.4% vs 27.5%, P < 0.05). Prevalence of male patients (74/88; 84.1%) was slightly higher among diabetic patients than the non-diabetic patients (60/80; 75%). Even though not significant, Kaplan-Meier survival curve showed that COVID-19 patients with diabetes had a shorter overall survival time than those without diabetes. In subgroup analysis, diabetic patients were classified into insulin-requiring and non-insulin-requiring groups based on their requirement of insulin during the stay in ICU. COVID-19 infected diabetic patients requiring insulin have high risk of disease progression and shorter survival time than the non-insulin required group.ConclusionsDiabetes is an independent risk factor for the poor prognosis of COVID-19. More attention should be paid to the prevention and prompt treatment of diabetic patients, to maintain good glycaemic control especially those who require insulin therapy. |
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Keywords: | Bangladesh COVID-19 Diabetes mellitus Epidemiology Clinical characteristics |
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