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Diabetes and COVID-19: A pooled analysis related to disease severity and mortality
Authors:Seshadri Reddy Varikasuvu  Naveen Dutt  Balachandar Thangappazham  Saurabh Varshney
Affiliation:1. Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Deoghar, Jharkhand, India;2. Department of Respiratory Medicine, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan, India;3. Department of Internal Medicine, All India Institute of Medical Sciences (AIIMS), Bibinagar, Telangana, India;4. Professor and Executive Director, All India Institute of Medical Sciences (AIIMS), Deoghar, Jharkhand, India
Abstract:Globally, COVID-19 has become a major concern for the diabetic community. We conducted a pooled analysis and constructed a forest plot for the association between diabetes and COVID-19 progression in 47 studies. A random effects meta-analysis (Mantel–Haenszel method) was conducted to estimate the outcomes effect size as odds ratios (OR) and 95% confidence intervals (CI) using Review Manager Software version 5.3. COVID-19 patients with diabetes have a significantly higher risk of disease severity (OR = 2.20, 95% CI = 1.69–2.86, p < 0.00001) and associated mortality outcomes (OR = 2.52, 95% CI = 1.93–3.30, p =  < 0.00001).
Keywords:COVID-19  Comorbidities  Diabetes
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