COVID-19 Infection in Men on Testosterone Replacement Therapy |
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Authors: | Amarnath Rambhatla Chandler J. Bronkema Nicholas Corsi Jacob Keeley Akshay Sood Ziad Affas Ali A. Dabaja Craig G. Rogers Stephen A. Liroff Firas Abdollah |
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Affiliation: | 1. Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA;2. School of Medicine, Wayne State University, Detroit, MI, USA;3. Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Detroit, MI, USA |
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Abstract: | BackgroundMen who contract coronavirus disease 2019 (COVID-19) appear to have worse clinical outcomes compared with women which raises the possibility of androgen-dependent effects.AimWe sought to determine if testosterone replacement therapy (TRT) is associated with worse clinical outcomes.MethodsThrough a retrospective chart review, we identified 32 men diagnosed with COVID-19 and on TRT. They were propensity score matched to 63 men diagnosed with COVID-19 and not on TRT. Data regarding comorbidities and endpoints such as hospital admission, intensive care unit admission, ventilator utilization, thromboembolic events, and death were extracted. Chi-square and Kruskal-Wallis tests examined differences in categorical and continuous variables, respectively. Logistic regression analysis tested the relationship between TRT status and the study endpoints.ResultsThere were no statistically significant differences between the 2 groups, and TRT was not a predictor of any of the endpoints on multivariate analysis.ConclusionThese results suggest that TRT is not associated with a worse clinical outcome in men diagnosed with COVID-19.Rambhatla A, Bronkema CJ, Corsi N, et al. COVID-19 Infection in Men on Testosterone Replacement Therapy. J Sex Med 2021;18:215–218. |
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Keywords: | Androgens COVID-19 Hypogonadism SARS-CoV-2 Testosterone Testosterone Replacement Therapy Venous Thromboembolism |
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