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Intrastriatal Quinolinic Acid Administration Impairs Redox Homeostasis and Induces Inflammatory Changes: Prevention by Kynurenic Acid |
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| Authors: | Ferreira Fernanda Silva Schmitz Felipe Marques Eduardo Peil Siebert Cassiana Wyse Angela T. S. |
| Affiliation: | 1.Programa de Pós-Gradua??o em Ciências Biológicas: Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600- Anexo, Porto Alegre, RS, 90035-003, Brazil ;2.Laboratório de Neuroprote??o e Doen?as Neurometabólicas, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil ;3.Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, CEP 90035-003, Porto Alegre, RS, 90035-003, Brazil ; |
| Abstract: | Neurotoxicity Research - Kynurenic acid (KYNA) and quinolinic acid (QUIN) are metabolites formed in the degradation of tryptophan (Trp). QUIN is a selective NMDA receptor antagonist and may exert... |
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