Association between lifestyle and site-specific advanced colorectal lesions in screening with faecal immunochemical test and sigmoidoscopy |
| |
| Authors: | Markus D Knudsen Edoardo Botteri Øyvind Holme Anette Hjartåker Mingyang Song Espen Thiis-Evensen Espen R Norvard Anna L Schult Kristin R Randel Geir Hoff Paula Berstad |
| |
| Institution: | 1. Section for colorectal cancer screening, Cancer Registry of Norway, P.O. Box 5313, Majorstuen, 0304 Oslo, Norway;2. Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Norwegian PSC Research Center, Oslo University Hospital, Rikshospitalet, P.O. Box 4950 Nydalen, 0424 Oslo, Norway;3. Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA;4. Department of Medicine, Sørlandet Hospital Kristiansand, P.O. Box 416 Lundsiden, 4604 Kristiansand, Norway;5. Department of Health Management and Health Economis, Institute of Health and Society, University of Oslo, P.O. Box 1089 Blindern, 0317 Oslo, Norway;6. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O.Box 1046 Blindern, 0317 Oslo, Norway;7. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA;8. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA;9. Department of Pathology, Vestre Viken Hospital Trust Drammen, P.O. Box 800, 3004 Drammen, Norway;10. Department of Medicine, Vestre Viken Hospital Trust Bærum, P.O. Box 800, 3004 Drammen, Norway;11. Institute of Clinical Medicine, University of Oslo, Rikshospitalet, P.O. Box 4950 Nydalen, 0424 Oslo, Norway;12. Department of Research and Development, Telemark Hospital Trust, Ulefossvegen 55, 3710 Skien, Norway |
| |
| Abstract: | BackgroundLifestyle factors may help to identify individuals at high-risk for colorectal cancer (CRC).AimsTo examine the association between lifestyle, referral for follow-up colonoscopy and proximal neoplasia detection in CRC screening.MethodsIn this observational study, 14,832 individuals aged 50–74 years were invited to faecal immunochemical test (FIT) or sigmoidoscopy screening. Advanced lesions (AL), including advanced adenomas, advanced serrated lesions and CRC were divided according to location: distal-only, or proximal with or without distal AL. We collected information on smoking habit, body mass index and alcohol intake through a questionnaire.ResultsOut of 3,318 FIT and 2,988 sigmoidoscopy participants, 516 (16%) and 338 (11%), respectively, were referred for follow-up colonoscopy after a positive screening test. Two-hundred-and-fifty-six (4%) had distal-only and 119 (2%) proximal AL. In FIT participants, obesity and high alcohol intake were associated with proximal AL; odds ratio (95% confidence interval) 2.68 (1.36–5.26) and 2.16 (1.08–4.30), respectively. In sigmoidoscopy participants, current smoking was associated with proximal AL; 4.58 (2.24–9.38), and current smoking and obesity were associated with referral for colonoscopy; 2.80 (2.02–3.89) and 1.42 (1.01–2.00), respectively.ConclusionCurrent smoking, obesity and high alcohol intake were associated with screen-detected proximal colorectal AL. Current smoking and obesity were associated with referral for follow-up colonoscopy in sigmoidoscopy screening. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
