Relationship between disease activity,organ damage and health-related quality of life in patients with systemic lupus erythematosus: A systemic review and meta-analysis |
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| Authors: | Yue Shi Mucong Li Lingshan Liu Ziqian Wang Yanhong Wang Jiuliang Zhao Qian Wang Xinping Tian Mengtao Li Xiaofeng Zeng |
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| Affiliation: | 1. Faculty of Pharmaceutical Sciences, The University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada;2. Arthritis Research Canada, 5591 No. 3 Road, Richmond, BC V6X 2C7, Canada;3. School of Pharmacy, University of Otago, Dunedin, New Zealand;4. Division of Rheumatology, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada;1. Systemic Autoimmune Diseases Research Unit, UMAE Manuel Ávila Camacho-CIBIOR Instituto Mexicano del Seguro Social, Puebla, Mexico;2. Department of Rheumatology, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico;3. Physiotherapy Program, Medical School, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico;4. Division of Health Research UMAE Manuel Ávila Camacho, Instituto Mexicano del Seguro Social Puebla, Puebla, Mexico;5. Department of Psychology, Medical School, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico;6. Medical School, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico;7. Puebla Research Coordination, High-Specialty Medical Unit, Specialty Hospital of Puebla, Instituto Mexicano del Seguro Social, Puebla, Mexico |
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| Abstract: | ObjectivesSystemic lupus erythematosus (SLE) is a common systemic autoimmune disease that may lead to considerable physical, psychological, and socioeconomical burden. In previous studies, inconsistent results were reported for the association of disease activity and organ damage with health-related quality of life (HRQoL). This paper aimed to explore the relationship between disease activity, organ damage, and HRQoL measured by SF-36, EQ-5D, LupusQoL, and LupusPRO and investigate whether the correlation is region-specific.MethodsWe systematically searched for studies reporting the association between SLE disease activity, organ damage, and HRQoL in MEDLINE, EMBASE, PsycINFO, World of Science, the Cochrane Library, and CINAHL from inception to December 2019. A meta-analysis and region subgroup analysis were performed with a random-effects model to estimate pooled correlation coefficients and heterogeneity.ResultsForty articles were included representing of 6079 adult SLE patients. The meta-analysis of SF-36 and LupusPRO studies revealed mild to moderate negative correlations between disease activity and domains of these HRQoL measurements (correlation coefficient r ranging from ?0.27 to ?0.07). Likewise, negative correlations were found between organ damage and domains of SF-36 and LupusPRO (r ranging from ?0.25 to ?0.08). The pooled correlation coefficient is relatively higher in physical functioning related domains than mental health. In the region subgroup analysis, disease activity had strong negative correlations with SF-36 domains in African and European SLE patients, while organ damage had the strongest negative correlation with SF-36 domains in Asian SLE patients (p < 0.010).ConclusionThis study provides the first comprehensive assessment of the relationship between disease activity, organ damage, and four popular HRQoL instruments, which provides useful insight into the target therapy in SLE management. |
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