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Desaturation and heme elevation during COVID-19 infection: A potential prognostic factor of heme oxygenase-1
Authors:Wen-Lin Su  Chih-Pei Lin  Hui-Ching Hang  Ping-Sheng Wu  Ching-Feng Cheng  You-Chen Chao
Affiliation:1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan;2. School of Medicine, Tzu Chi University, Hualien, Taiwan;3. Department of Pathology and Laboratory Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan;4. Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan;5. Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan
Abstract:Increased heme levels, anemia, and desaturation occur during infection. We aimed to compare the levels of heme, heme oxygenase-1 (HO-1), ferritin, and bilirubin in coronavirus disease 2019 (COVID-19) patients at different saturation levels. Heme and HO-1 enzyme levels significantly increased in the low SpO2 group, but further studies are required.
Keywords:COVID-19  Heme  Heme oxygenase-1  SARS-CoV-2
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