Extraintestinal manifestation of inflammatory bowel disease in Asian patients: A multinational study |
| |
| Authors: | Soo-Kyung Park Zhiqin Wong Sang Hyoung Park Khien Van Vu Ki Bae Bang Panida Piyachaturawat Thein Myint Ida Hilmi Dong-Il Park |
| |
| Affiliation: | 1. Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, 29 Saemunan-ro, Jongno-gu, Seoul, Republic of Korea;2. Gastroenterology Unit, Department of Medicine, Faculty of Medicine, National University Of Malaysia, Kuala Lumpur, Malaysia;3. Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea;4. Department of GI Endoscopy, 108 Military Central Hospital, Hanoi, Vietnam;5. Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea;6. Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross, Bangkok, Thailand;7. Department of Gastroenterology, Yangon General Hospital, Yangon, Myanmar;8. Division of Gastroenterology and Hepatology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia |
| |
| Abstract: | Background/aimAlthough inflammatory bowel disease (IBD) incidence has increased over the past two decades in Asia, data on extraintestinal manifestations (EIMs) of IBD in Asian patients are limited. We aimed to evaluate the prevalence and clinical characteristics of EIMs in Asian IBD patients.MethodsIn total, 1,764 patients (1,130 with ulcerative colitis [UC] and 634 with Crohn's disease [CD]) were recruited from 10 tertiary centers in Asia. The medical records of IBD patients were retrospectively reviewed for the presence, clinical characteristics, chronological order, and therapeutic management of EIMs.ResultsEIMs were reported in 199 (11.3%) patients, of which 17 (1.0%) patients had multiple EIMs. EIMs were more prevalent in CD patients (P = 0.02). Multiple logistic regression analysis revealed that female sex (odds ratio [OR] 2.02, 95% confidence interval [CI] 1.15–3.55), stricture (OR 2.49, 95% CI 1.41–4.39) and female sex (OR 2.57, 95% CI 1.52–4.34), extensive colitis (OR 2.63, 95% CI 1.57–4.41) were associated with EIMs in CD and UC patients respectively. EIMs appeared in 8% of patients before IBD diagnosis; 95% of cases with EIM could be managed via first-line therapy.ConclusionEIM prevalence is lower among Asian IBD patients than among patients from Western countries; however, the risk factors for EIM were similar between both populations. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
