Opportunistic body composition evaluation in patients with esophageal adenocarcinoma: association of survival with 18F-FDG PET/CT muscle metrics |
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Authors: | Zhou Cathy Foster Brent Hagge Rosalie Foster Cameron Lenchik Leon Chaudhari Abhijit J Boutin Robert D |
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Institution: | 1.Department of Radiology, UC Davis School of Medicine, 4860 Y Street, Suite 3100, Sacramento, CA, 95817, USA ;2.Biomedical Engineering, University of California Davis, Sacramento, CA, 95616, USA ;3.Radiology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA ;4.Radiology, Stanford University School of Medicine, Stanford, CA, 94305, USA ; |
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Abstract: | Objective 18F-FDG PET is widely used to accurately stage numerous types of cancers. Although 18F-FDG PET/CT features of tumors aid in predicting patient prognosis, there is increasing interest in mining additional quantitative body composition data that could improve the prognostic power of 18F-FDG PET/CT, without additional examination costs or radiation exposure. The aim of this study was to determine the association between overall survival and body composition metrics derived from routine clinical 18F-FDG PET/CT examinations. MethodsPatients who received baseline 18F-FDG PET/CT imaging during workup for newly diagnosed esophageal adenocarcinoma (EAC) were included. From these studies, psoas cross-sectional area (CSA), muscle attenuation (MA), SUVmean, and SUVmax were obtained. Correlation with overall survival was assessed using a Cox Proportional Hazards model, controlling for age, body mass index, 18F-FDG dose, glucose level, diabetes status, in-hospital status, and tumor stage. ResultsAmong the 59 patients studied, psoas MA and SUVmax were found to be significant predictors of survival (HR 0.94, 95% CI 0.88–0.99, p?=?0.04, and HR 0.37, 95% CI 0.14–0.97, p?=?0.04, respectively) and remained independent predictors. Psoas CSA and SUVmean did not significantly influence survival outcomes. ConclusionsCharacterization of psoas muscles as a surrogate marker for sarcopenia on baseline 18F-FDG PET/CT imaging is relatively easily obtained and may offer additional prognostic value in patients with EAC. |
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