Importance of hyperglycemia in COVID-19 intensive-care patients: Mechanism and treatment strategy |
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| Authors: | Fatemeh Mirzaei Iraj Khodadadi Seyyed Alireza Vafaei Ebrahim Abbasi-Oshaghi Heidar Tayebinia Farhad Farahani |
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| Affiliation: | 1. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran;2. Department of Anatomical Sciences, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran;3. Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran;4. Islamic Azad University of Sanandaj, Department of Biology, Sanandaj, Iran;5. Hearing Impairment Research Center, Hamadan University of Medical Sciences, Hamadan, Iran |
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| Abstract: | This review reported that coronavirus disease 2019 (COVID-19) infected patients with short time bed rest or quarantine and airway inflammation are at more risk of developing hyperglycemia and insulin resistance. This condition can induce oxidative stress, decrease immune system function, impair endothelial function, induce apoptosis, and reduce antioxidant in the lungs. We provide a possible mechanism in severe COVID-19 patients and recommend treatment strategy to reduce mortality rate and prevent adverse outcomes after intensive care unit (ICU). |
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| Keywords: | Coronavirus COVID-19 Diabetes Hyperglycemia Oxidative stress SARS-CoV-2 |
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