Efficacy of uremic pruritus treatment in patients undergoing hemodialysis,a network meta-analysis for randomized clinical trials |
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| Authors: | Wei-Wei Feng Bo Yuan Fang-Yuan Shen Wang-Yang Fan Di-Sen Mei Bei-Yan Bao Qi-Jun Chen |
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| Affiliation: | 1. Nephrology Department, Ningbo Yinzhou No. 2 Hospital, 315010 Ningbo, China;2. Dermatology Department, The Affiliated Hospital of Medical School, Ningbo University, 315020 Ningbo, China;3. Ningbo University School of Medicine, 315211 Ningbo, China;1. Aix-Marseille University, Department of Nephrology, AP–HM, La Conception Hospital, 147, boulevard Baille, 13005 Marseille, France;2. Aix-Marseille University, Department of Anaesthesiology and Intensive Care, AP–HM, Nord Hospital, Marseille, France;3. C2VN Laboratory, Inserm 1263, INRAE 1260, Aix-Marseille University, Marseille, France;4. Aix-Marseille University, Department Digestive Surgery, AP–HM, La Timone Hospital, Marseille, France;1. Department of Nephropathy, Third Xiangya Hospital of Central South University, 410013 Changsha, Hunan Province, China;2. Department of anesthesiology, Third Xiangya Hospital of Central South University, 410013 Changsha, Hunan Province, China;1. Health sciences university, Umraniye training and research hospital clinic of Nephrology, Elmalikent district, Adem Yavuz Street, No: 1, 34760 Umraniye, Istanbul, Turkey;2. Health Sciences University, Umraniye training and research hospital clinic of Pathology Umraniye, Istanbul, Turkey;3. Health Sciences University, Umraniye training and research hospital clinic of Internal Medicine, Istanbul, Turkey;1. Université Mohammed-V de Rabat, Rabat, Maroc;2. Service de chirurgie vasculaire, centre hospitalo-universitaire Ibn-Sina, 10104 Rabat, Souissi, Maroc;1. Association Dialyse Provence Corse, 11 rue Jules Isaac 13009 Marseille, France;1. Clinical Cares and Skills Research Center, Department of Medical Surgical Nursing, School of Nursing and Midwifery, Yasuj University of Medical Sciences, Yasuj, IR Iran;2. Department of Medical Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, IR Iran;3. Department of Medical Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran;4. School of Health, Iran University of Medical Sciences, Iran;5. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | IntroductionUremic pruritus is very common in hemodialysis or renal failure patients, there were lots of available treatments such as gabapentin, pregabalin, ondansetron, etc. However, there is no quantified study comparing these treatments together, it is impossible to conduct a clinical trial involving so many treatments, so we conduct a network meta-analysis to compare them.MethodWe collected mean difference and standard error of visual analogue scale data as outcome. In total we collected 15 articles, 15 articles, 1180 subjects and 6 treatments included to this study.ResultsIn these comparisons, gabapentin showed the largest effect MD: 5.19, 95% CI [3.77, 6.61], anti-histamine MD: 4.65, 95% CI [2.22, 7.07] and pregabalin MD: 4.62, 95%CI [2.71, 6.62] showed a similar effect. Opioid pathway related treatment also showed a significant but not so large effect MD: 2.45, 95% CI [0.41, 4.49]. Ondansetron and Doxepin didn’t show a significant improvement among placebo, the overall quantifying heterogeneity I2 = 43.1%. There is no statically difference between gabapentin, pregabalin and anti-histamine treatments.ConclusionsSo we conclude that gabapentin, pregabalin and anti-histamine has a similar efficacy on pruritus control. |
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| Keywords: | Hemodialysis Network meta-analysis Randomized clinical trials Uremic pruritus |
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