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Variables associated with insulin production in persons with type 2 diabetes treated with multiple daily insulin injections |
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| Authors: | Klara Westman Henrik Imberg Henrik Albrektsson Irl B. Hirsch Jaakko Tuomilehto Sofia Dahlqvist Marcus Lind |
| Affiliation: | 1. Department of Medicine, NU-Hospital Group, Trollhättan/Uddevalla, Sweden;2. Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden;3. Statistiska Konsultgruppen, Gothenburg, Sweden;4. Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden;5. University of Washington School of Medicine, UW Medicine Diabetes Institute, Seattle, WA 98109, United States;6. Public Health Promotion Unit, Finnish Institute for Health and Welfare, P.O. Box 30, 00271 Helsinki, Finland;7. Department of Public Health, University of Helsinki, 00014 Helsinki, Finland;8. Saudi Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia |
| Abstract: | From the MDI-liraglutide study, we evaluated variables associated with endogenous insulin production in persons with multiple daily insulin injections-treated type 2 diabetes by relating C-peptide, proinsulin and proinsulin/C-peptide ratio at baseline to baseline variables. Lower insulin production was related to longer diabetes duration, shorter abdominal sagittal diameter and more glycaemic variability. |
| Keywords: | Type 2 diabetes mellitus Multiple daily insulin injections Insulin secretion C-peptide and proinsulin and related variables |
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