辅助生殖技术治疗中子宫畸形对妊娠结局的影响

目的 探讨不孕女性行辅助生殖技术(ART)助孕治疗过程中子宫畸形对妊娠结局的影响。方法 选取2015年5月至2021年5月期间于皖南医学院第一附属医院弋矶山医院生殖医学中心接受ART助孕的不孕女性中子宫畸形患者作为试验组纳入,共34周期;机械抽样选取同时期接受ART助孕符合纳入标准的子宫正常的患者,作为对照组纳入,共73周期。收集两组患者的一般资料、激素水平、试验室指标、妊娠结局进行回顾性分析;依据子宫畸形的不同类型将试验组分为5组,分别对5组患者妊娠结局进行统计。结果 子宫正常组与子宫畸形组的临床妊娠率、单胎率、双胎率、活产率、早期流产率、中晚期流产率比较,差异无统计学意义(P>0.05)。子宫畸形5个亚组,临床妊娠率、单胎率、双胎率、活产率、早期流产率、中晚期流产率比较,差异均无统计学意义(P>0.05)。结论 ART治疗中子宫畸形不是妊娠结局的主要影响因素。

Analysis and discussion of pregnancy outcomes of malformed uterus in ART treatment

Objective To investigate the effect of uterine malformation on pregnancy outcome in infertile women receiving assisted reproductive technology (ART).Methods Patients with uterine malformation who received ART assisted pregnancy in Reproductive Medicine Center of Yijishan Hospital, the First Affiliated Hospital of Wannan Medical College from May 2015 to May 2021 were included as the experimental group, a total of 34 cases (cycles). Mechanical sampling was used to select patients with normal uterus who received ART assisted pregnancy and met inclusion criteria at the same period as the control group, with a total of 73 cycles. The general data, hormone levels, laboratory indicators and pregnancy outcomes of the two groups were retrospectively analyzed. According to the different types of uterine malformation, the experimental group was divided into four groups, and the pregnancy outcomes of the four groups were statistically analyzed.Results There were no significant differences in clinical pregnancy rate, single pregnancy rate, twin pregnancy rate, live birth rate, early abortion rate and middle and late abortion rate between normal uterus group and abnormal uterus group (P>0.05). There were no significant differences in clinical pregnancy rate, singleton rate, twin rate, live birth rate, early abortion rate, and late abortion rate among the four subgroups of uterine malformations (P>0.05).Conclusions Uterine malformation is not a main factor affecting pregnancy outcome in ART treatment.