阿立哌唑对精神分裂症患者失匹配性负波电位的影响

目的 探讨阿立哌唑对精神分裂症患者失匹配性负波电位(MMN)的影响.方法 随机选自18～65岁符合DSM-精神分裂症标准患者30例作为研究组,30例健康人作为对照组.研究组于阿立哌唑治疗前、4,8周后予MMN检测,同时予PANSS评定病情严重程度.对照组入组时预MMN检测.观察MMN波幅、潜伏期的变化.结果 研究组在治疗4,8周后PANSS量表分低于基线水平(均P＜0.05).研究组频率偏离MMN波幅及持续时间偏离MMN波幅均低于对照组(均P＜0.05).将MMN型与治疗时间层面作为组间因素的重复测量的方差分析显示,研究组频率偏离MMN与持续时间偏离MMN两组波幅间交互作用不显著；治疗时间层面间存在显著效应.治疗8周后MMN波幅比基线水平、治疗4周后明显升高(均P＜0.05).结论 精神分裂症患者存在认知功能损害,MMN提供了阿立哌唑能够改善精神分裂症认知功能的证据.

Effect of treatment with Aripiprazole on mismatch negativity potentials in schizophrenia

Objective To study the effects of Aripiprazole on mismatch negativity potentials in schizophrenia. Methods 30 patients （age of 18-65 years old） met DSM-IV schizophrenia criteria were enrolled as research group and 30 healthy persons were selected as normal control group that performed the frequency and duration deviant MMN task. MMN latency and amplitude at Fz electrodes were obtained. The research group was treated with Quetipine for 8 weeks and assessed with PANSS. MMN amplitudes and latencies of two groups were compared between the groups. Results Aripiprazole decreased all PANSS scales （P〈0.05）. Patients showed smaller mean amplitudes of frequency and duration MMN than that of normal controls （P〈0.05）. A repeated measure ANOVA in MMN type （frequency vs. duration） and session as between-subject factors revealed no significant MMN type or MMN type X session interaction for MMN amplitudes but significant effects of session. A multiple comparisons by LSD tests demonstrated significant differences in MMN amplitudes at after 8-week treatment from that at baseline （P （0.05） and after 4-week treatment （P〈0.05）. There was no significant differences in MMN amplitudes between 4-week treatment and baseline （P〉0.05）. MMN amplitudes at 8c week treatment were higher than that at 4-week treatment and at baseline （P （0.05）. Conclusions It presents cognitive dysfunction in schizophrenia. In neuroelectrophysical aspect,MMN offers objective evidence for Aripiprazole to improves cognitive function in Schizophrenia.