补肾活血化痰法对多囊卵巢综合征患者血清瘦素的影响

目的观察补肾活血化痰法组方中药对多囊卵巢综合征（PCOS）患者血清瘦素（Lep-tin）水平变化的影响。方法将90例PCOS患者随机分为三组,中药治疗组30例,采用补肾活血化痰法中药治疗;中西药治疗组30例,采用补肾活血化痰法中药＋西药（达英-35＋二甲双胍）治疗,对照组30例,采用达英-35＋二甲双胍治疗,连续治疗3个月经周期。检测三组患者治疗前后血清中Leptin浓度以及卵泡刺激素（FSH）、黄体生成素（LH）、睾酮（T）数值,并进行比较。结果治疗后三组LH、LH/FSH、T、Leptin水平均较治疗前降低,治疗前后组内比较差异有统计学意义（P〈0.05）;中药治疗组与西药对照组比较,对以上四组数值的影响并无明显优势（P〉0.05）,而中西医治疗组与西药对照组比较,虽然LH、LH/FSH的治疗前后组间比较差异无统计学意义,但中西医治疗组T、Leptin水平比西药治疗组变化更为显著,组间比较差异有统计学意义（P〈0.05）。结论补肾活血化痰中药联合达英-35、二甲双胍能有效降低PCOS患者的血清Leptin水平,治疗效果优于单纯使用中药或西药。

Impacts on Serum Leptin for the Patients with Polycystic Ovary Syndrome Treated with the Therapy for Tonifying the Kidney,Activating Blood Circulation and Resolving Phlegm

Objective To observe the impacts of serum leptin for the patients with polycystic ovary syndrome(PCOS)treated with the herbal recipe for tonifying the kidney,activating blood circulation and resolving phlegm.Method 90 cases of PCOS were randomized into three groups.In a Chinese medicine treatment group(30 cases),Chinese herbal therapy was adopted for tonifying the kidney,activating blood circulation and resolving phlegm.In an integrated Chinese and western medicine treatment group(30 cases),Chinese herbal therapy(tonifying the kidney,activating blood circulation and resolving phlegm)+ western medicine(Diane-35 + metformin)was adopted.In a control group(30 cases),Diane-35 + metformin was adopted.The treatment lasted continuously for 3 menstrual cycles.The values of leptin concentration,follicle stimulating hormone(FSH),luteinizing hormone(LH)and testosterone(T)in the serum were observed before and after treatment and made the comparison.Results After treatment,the levels of LH,LH/FSH,T and leptin were all reduced as compared with those before treatment.The statistical significant differences presented in the within-group before and after treatment(P<0.05).In the comparison between the integrated Chinese and western medicine treatment group and the western medicine treatment group,there were no statistical significant differences in the values of LH and LH/FSH before and after treatment,but the levels of T and leptin in the integrated Chinese and western medicine group changed much more significantly as compared with those in the western medicine treatment group,presenting the statistical significant difference(P<0.05).Conclusions The Chinese herbal therapy for tonifying the kidney,activating blood circulation and resolving phlegm combined with Diane-35 and metformin effectively reduces the serum leptin level for PCOS patients and the efficacy is superior to that of either simple Chinese medicine or western medicine.