尿中性粒细胞明胶酶相关性脂质运载蛋白检测对SLE肾病的临床意义

目的探讨尿中性粒细胞明胶酶相关性脂质运载蛋白(NGAL)在系统性红斑狼疮(SLE)患者肾脏损伤中的临床意义。方法收集124例SLE患者和30名健康体检者尿液,采用速率散射比浊法检测尿微量白蛋白(Albu),并依据尿中Albu将SLE患者分为A、B、C 3组。30名健康体检者为对照组,用酶免疫法定量测定各组NGAL。结果 SLE患者A、B、C 3组和对照组尿NGAL分别为3.51±0.49、5.48±0.987、.89±1.71、3.37±0.31μg/L;A组(Albu<30mg/L)和对照组间差异无统计学意义(P>0.05);B组(Albu 30～100 mg/L)和对照组间差异有统计学意义(P<0.01);C组(Albu 100～500 mg/L)和对照组间差异有统计学意义(P<0.01);A、B、C3组间差异有统计学意义(P<0.05)。SLE患者尿NGAL与Albu之间呈正相关性(r=0.84)。结论当Albu增高时尿NGAL随之增高,尿NGAL可用于判断SLE患者肾小管间质功能损伤情况。

The clinical significance of detecting urinary neutrophil gelatinase-associated lipocalin in SLE kidney disease

Objective To investigate the clinical significance of urinary neutrophil gelatinase-associated lipocalin(NGAL) in kidney damage of systemic lupus erythematosus(SLE) patients.Methods The urine of 124 SLE patients and 30 healthy subjects were collected.The urinary microalbumin(Albu) was detected by rate nephelometry.According to the results of Albu,the SLE patients were classified into 3 groups(Group A,B and C).The 30 healthy subjects were as the control group.The NGAL was detected by enzyme immunoassay quantitatively.Results The urinary NGAL in Group A,B and C of SLE patients and control group were 3.51±0.49,5.48±0.98,7.89±1.71 and 3.37±0.31 μg/L.There was no statistical significance of urinary NGAL between Group A(Albu<30mg/L) and control group(P>0.05).There was statistical significance of urinary NGAL between Group B(Albu: 30-100 mg/L) and control group(P<0.01).There was statistical significance of urinary NGAL between Group C(Albu: 100-500 mg/L) and control group(P<0.01).There was statistical significance of urinary NGAL among Group A,B and C(P<0.05).The positive correlation about the Albu and urinary NGAL was 0.84 in SLE patients.Conclusions Urinary NGAL increases when Albu rises,and urinary NGAL can be used to judge SLE patients with tubular interstitial function damage.