细胞因子与2型糖尿病周围神经病变的相关性研究

目的 观察细胞因子TNF-α、IL-1β和IL-6在2型糖尿病周围神经病变患者的表达并分析其相关性.方法 收集在本院住院治疗的120例2型糖尿病患者及60例正常体检者的病史和临床生化资料,2型糖尿病患者根据有无周围神经病变分成两组:单纯2型糖尿病组与2型糖尿病周围神经病变组.ELISA法分别测定两组患者的细胞因子TNF-α、IL- 1β和IL-6.采用多因素相关分析方法,分析细胞因子与2型糖尿病周围神经病变之间的关系.结果 对照正常组与单纯2型糖尿病组,FBG、PPG、HbAlc、Hs-CRP、TNF-α和IL- 1β在2型糖尿病周围神经病变组表达明显增高,具有统计学意义(P＜0.05).多因素相关分析显示Hs-CRP、TNF-α和HbAlc对2型糖尿病是否合并周围神经病变均有独立作用.结论 免疫炎性反应参与了2型糖尿病周围神经病变的发生.

Association of cytokines with diabetic peripheral neuropathy in type 2 diabetes mellitus

Objective To investigate the effect of cytokines on diabetic peripheral neuropathy in type 2 diabetes mellitus. Methods 120 patients with type 2 diabetes mellitus and 60 control were collected. Patients of type 2 diabetes mellitus were divided into two groups： type 2 diabetes mellitus group and diabetic peripheral neuropathy group. TNF-α, IL-16 and IL-6 were detected, and the main associated factors were collected and analyzed by one-way ANOVA and logistic regression. Results ompared with the group of type 2 diabetes mellitus and control, the level of FBG,PPG, HbAlc , Hs-CRP, IL-16 and TNF-α in the group of diabetic peripheral neuropathy showed an statistically significant increase （P 0.05）. TNF-α, Hs-CRP and HbAlc were further found to be risk factors for peripheral neuropathy in type 2 diabetes mellitus. Conclusions Immunological and inflammatory reactions play a key role in developing peripheral neuropathy in type 2 diabetes mellitus patients.